Last updated: April 29, 2022

Summarytoggle arrow icon

The esophagus is the muscular tube derived from the foregut that carries food and liquid from the oropharynx to the stomach. It crosses the diaphragm at the esophageal hiatus, which is located at the level of the tenth thoracic vertebra (T10). The esophagus has an upper sphincter, which prevents the entry of air, and a lower sphincter, which prevents the reflux of gastric acid. Food is transported by peristaltic movements of the esophageal muscles. The esophagus is supplied by the esophageal branches of the inferior thyroid artery, the thoracic aorta, and the left gastric arteries. The veins of the esophagus drain into the systemic circulation via the azygos and the hemiazygos veins and into the portal circulation via the left gastric veins. Portal hypertension results in esophageal varices, which are supplied by the left gastric veins. The esophageal wall consists of four concentric layers: mucosal, submucosal, muscular, and adventitia. The mucosa is lined by nonkeratinizing stratified squamous epithelium that transitions to columnar epithelium at the gastroesophageal junction. In gastroesophageal reflux disease (GERD), chronic acid exposure induces metaplasia of the lower esophageal squamous epithelium to gastric columnar epithelium (Barrett esophagus). Other diseases that may affect the esophagus include esophageal stricture, esophageal atresia, achalasia, and esophageal cancer.

Gross anatomytoggle arrow icon



  • Passage for food and liquids between the oropharynx and stomach
    • Peristaltic contractions of the esophageal muscles assist in moving food downwards.


Cervical portion Thoracic portion Abdominal portion
  • Esophageal branches of left gastric arteries
  • Azygos and hemiazygos veins
Enteric nervous system
Arteries Veins Lymphatics
Cervical portion
Thoracic portion
  • Azygos and hemiazygos veins
Abdominal portion
  • Esophageal branches of left gastric arteries


Microscopic anatomytoggle arrow icon

Embryologytoggle arrow icon

  • Derived from the embryonic foregut
  • Fusion of lateral mesodermal ridges in the midline separates the esophagus from the trachea at 26 days' gestation

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