Scabies is a parasitic skin infestation caused by the Sarcoptes scabiei var. hominis (S. scabiei) mite, which is primarily transmitted via direct human-to-human contact. The female scabies mite burrows into the superficial skin layer, causing severe pruritus, particularly at night. Primary lesions commonly include erythematous papules, vesicles, or burrows. Treatment involves topical medical therapy (e.g., permethrin) and decontamination of all clothing and textiles.
- Pathogen: Sarcoptes scabiei var. hominis
- Risk factors: : crowded living conditions (e.g., institutions such as nursing homes, child care facilities, and prisons) 
- The fertilized, female mite tunnels into the superficial skin layer (stratum corneum), forming burrows in which she lays her eggs and deposits feces (scybala).
- After 2 months, the female parasite dies on site.
- Following a period of 3 weeks, the larvae mature into adult mites, maintaining the infestation cycle.
- The excretions of the mites and their decomposing bodies contain antigens which cause an immunological response (see , presenting as severe pruritus and excoriations.
- Incubation period: approximately 3–6 weeks following infestation.
- Intense pruritus that increases at night 
- Burning sensation
- Skin lesions
- Predilection sites
- Wrists (flexor surface)
- Medial aspect of fingers
- Interdigital folds (hands and feet)
- Male genitalia (e.g., scrotum, penis)
- All other intertriginous areas of the skin (anterior axillary fold, buttocks)
- Areas surrounding the nipple (mamillary region)
- Periumbilical area or waist
- Knees (flexor surface)
- Feet (dorsal and lateral aspect)
- Additionally in children, elderly persons, and immunosuppressed patients: scalp, face, neck, under the nail, palms of hands, and soles of feet
Subtypes and variants
Crusted scabies (Norwegian scabies)
- Definition: a rare, severe, and highly contagious form of scabies that presents with a large number of scabies mites and eggs on the skin
- Epidemiology: typically occurs in immunosuppressed (e.g., HIV), debilitated, or elderly patients
- Slightly pronounced or absent pruritus
- Typical areas include the scalp, hands, and feet
- May involve the whole integument (especially if left untreated)
- Treatment: rapid and aggressive medical therapy with a scabicidal agent to prevent an outbreak
- Typical history and skin lesions on clinical examination (see “Symptoms/clinical findings” above)
- Environmental diagnosis (direct contact with infected persons)
- Detection of mites, larvae, ova, or mite feces
- Definition: ectoparasitic arthropods of the Cimicidae family that feed on blood (typically at night, while individuals are asleep) and whose bite leaves a painless papule that typically becomes pruritic over time
- Pathogen: Cimex lectularius
- Transmission: direct contact with infested beds and other furniture and/or travelers who bring home bed bugs or their eggs (e.g., on clothes, in luggage) from stays in infested residences
- Risk factors: crowded, unsanitary living conditions
- Clinical features
- Consult a pest control service
- Detection of bed bugs in the patient's environment confirms the diagnosis
- Prognosis: bites usually resolve spontaneously within 7 days
The differential diagnoses listed here are not exhaustive.
Medical therapy: topical application of a scabicidal agent
- Drug of choice: permethrin 5% lotion
- Symptomatic treatment of pruritus
- All close contacts should receive prophylactic treatment.
- Wash all textiles (e.g., clothing and bedding) (day 1 and day 8 post-treatment)
- All contacts within the household should be treated for scabies infestation even if asymptomatic.
The local health care department should be notified of a suspected threat of community outbreak of scabies and the following measures implemented for:
Single noncrusted case
- Following direct contact with the skin or a patient with scabies, hands should be thoroughly washed (also underneath the nails), then disinfected with an agent that is effective against scabies mites.
- Appropriate identification and treatment of scabies in the affected individual, with adequate follow-up. All contacts (including within the hospital) should receive prophylactic treatment.
- Avoid skin-to-skin contact for 8 hours after initial treatment.
- Increased surveillance for new cases
Multiple noncrusted cases
- In addition to the above, an institution-based awareness and education program
- Adequate recording of epidemiological data
- Crusted scabies case: same as above, but more rapid and aggressive approach