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Seronegative spondyloarthropathies

Last updated: December 19, 2020

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Seronegative spondyloarthropathies include several chronic inflammatory arthritic diseases that affect the vertebral column. The most important diseases in this group are ankylosing spondylitis, reactive arthritis, and psoriatic arthritis. Common features include the absence of rheumatoid factor (RF) and a strong genetic association with HLA-B27. Spondyloarthropathies disproportionately affect men, with symptom onset generally occurring before the age of 45. The cardinal sign is slowly progressive pain in the lower back and sacroiliac joints (especially at night). Asymmetrical oligoarthritis and enthesopathy are also common. The diseases differ in the involvement of other organs, such as the eyes, the genitourinary tract (particularly in reactive arthritis) or the skin (particularly in psoriatic arthritis). Seronegative spondyloarthropathies usually respond well to NSAID therapy.

The different types of seronegative spondyloarthropathy do not necessarily represent distinct diseases but may overlap significantly in etiology, pathology, clinical features, and treatment.

A-PAIR of conditions is commonly associated with HLA-B27: Ankylosing spondylitis, Psoriasis, Acute anterior uveitis, Inflammatory bowel disease, Reactive arthritis.

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