Ischemic hepatitis

Last updated: June 7, 2023

Summarytoggle arrow icon

Ischemic hepatitis refers to acute, diffuse liver injury due to hypoperfusion. The most common causes of hepatic hypoperfusion are cardiopulmonary failure and shock. Clinical presentation varies and may be asymptomatic or involve abdominal pain, nausea, vomiting, and anorexia. Diagnosis is established based on medical history (e.g., history of heart failure) and severely elevated serum aminotransferase levels, elevated LDH, and bilirubin levels. Management consists of treating the underlying condition and hemodynamic support.

Epidemiologytoggle arrow icon

Epidemiological data refers to the US, unless otherwise specified.

Pathophysiologytoggle arrow icon

Pathophysiology of hepatic tissue hypoxia and necrosis:

Clinical featurestoggle arrow icon

Diagnosticstoggle arrow icon

Pathologytoggle arrow icon

Differential diagnosestoggle arrow icon

The differential diagnoses listed here are not exhaustive.

Managementtoggle arrow icon

There is no specific treatment for ischemic hepatitis.

Prognosistoggle arrow icon

Referencestoggle arrow icon

  1. Tapper EB, Sengupta N, Bonder A. The Incidence and Outcomes of Ischemic Hepatitis: A Systematic Review with Meta-analysis. Am J Med. 2015; 128 (12): p.1314-1321.doi: 10.1016/j.amjmed.2015.07.033 . | Open in Read by QxMD
  2. Clemens MM, McGill MR, Apte U. Mechanisms and biomarkers of liver regeneration after drug-induced liver injury. Elsevier ; 2019: p. 241-262
  3. Feldman M, Friedman LS, Brandt LJ. Sleisenger and Fordtran's Gastrointestinal and Liver Disease- 2 Volume Set. Elsevier ; 2020
  4. Fuhrmann V, Kneidinger N, Herkner H, et al. Impact of hypoxic hepatitis on mortality in the intensive care unit.. Intensive Care Med. 2011; 37 (8): p.1302-10.doi: 10.1007/s00134-011-2248-7 . | Open in Read by QxMD
  5. Raurich JM, Llompart-Pou JA, Ferreruela M, et al. Hypoxic hepatitis in critically ill patients: incidence, etiology and risk factors for mortality.. J Anesth. 2011; 25 (1): p.50-6.doi: 10.1007/s00540-010-1058-3 . | Open in Read by QxMD

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