Uveal melanoma

Last updated: September 22, 2023

Summarytoggle arrow icon

Uveal melanoma is the most common primary malignant tumor of the eye. It develops from choroidal melanocytes and is therefore often pigmented. The tumor can arise from the choroid, iris, or ciliary body. Symptoms, which depend on the location of the tumor, begin when the tumor extends to the optical axis or if there is concomitant retinal detachment or interference with the function of the ciliary body or pupil. The condition is diagnosed through fundoscopy and ultrasonography. Treatment usually consists of radiation therapy or surgical removal of the tumor in advanced disease. With the exception of iris melanoma, uveal melanoma is typically diagnosed late because of the lack of early symptoms. Approximately half of patients go on to develop distant metastases via hematogenous spread, most commonly to the liver, which are then fatal.

Epidemiologytoggle arrow icon


Epidemiological data refers to the US, unless otherwise specified.

Etiologytoggle arrow icon


Clinical featurestoggle arrow icon

Symptoms vary depending on melanoma location.

Diagnosticstoggle arrow icon


Pathologytoggle arrow icon

  • Cytology
    • Spindle-shaped cells: best prognosis
      • Type A: thin nucleus and no visible nucleoli
      • Type B: large nucleus and visible nucleoli
    • Epithelioid melanoma (poor prognosis): large polygonal cells and prominent nucleoli
    • Intermediate cells: similar to epithelioid cells, but smaller
  • Histopathology
    • Mixed-cell melanoma, which includes variable proportions of the three cell types, is the most common form.
    • Tumor cells with a bundle-like arrangement, which may have brown intracellular melanin in some areas

Differential diagnosestoggle arrow icon

The differential diagnoses listed here are not exhaustive.

Treatmenttoggle arrow icon


Complicationstoggle arrow icon

We list the most important complications. The selection is not exhaustive.

Prognosistoggle arrow icon


Referencestoggle arrow icon

  1. Intraocular (Uveal) Melanoma Treatment (PDQ®) – Health Professional Version. Updated: September 20, 2018. Accessed: December 2, 2018.
  2. Singh P, Singh A. Choroidal melanoma. Oman J Ophthalmol. 2012; 5 (1): p.3-9.doi: 10.4103/0974-620X.94718 . | Open in Read by QxMD
  3. Jovanovic P, Mihajlovic M, Djordjevic-Jocic J, Vlajkovic S, Cekic S, Stefanovic V. Ocular melanoma: an overview of the current status. Int J Clin Exp Pathol. 2013; 6 (7): p.1230-44.
  4. Kivelä T. Diagnosis of uveal melanoma. KARGER ; 2011: p. 1-15
  5. Grehn F. Augenheilkunde. Springer Verlag (2005) ; 2006
  6. Lang GK, et al.. Augenheilkunde. Thieme Verlag (2008) ; 2008

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 Evidence-based content, created and peer-reviewed by physicians. Read the disclaimer