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Diseases of the vitreous body

Last updated: March 24, 2021

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The vitreous body is the transparent, gelatinous substance that fills the space of the eye between lens and retina. It allows light to pass from the lens to the retina and normally has enough mass to maintain the eyeball's spherical shape and counteract retinal detachment. This article covers the most common diseases of the vitreous body, including posterior vitreous detachment and vitreous hemorrhage.
Posterior vitreous detachment is the separation of the posterior vitreous cortex from the internal limiting membrane of the retina. Etiologies include age-related degeneration of the vitreous tissue, elongation of the ocular bulb, and eye injuries. Patients are usually asymptomatic, but may complain of floaters and photopsia. Vitreous detachment is confirmed on slit lamp examination. Asymptomatic individuals do not require treatment. Symptomatic individuals with retinal injury (e.g., retinal tears/holes, retinal detachment) require prompt treatment with, e.g., laser photocoagulation.
Vitreous hemorrhage is the extravasation of blood into the vitreous body and its adjacent structures. It can be caused by trauma and a variety of diseases, e.g., proliferative diabetic retinopathy, posterior vitreous detachment, and tumors. Clinical features include painless sudden onset of unilateral floaters and/or visual loss. Slit lamp examination confirms the presence blood in the vitreous body. Initially, a wait-and-see approach is recommended, since the condition typically resolves spontaneously. However, if the retina is affected or severe disease progression occurs, vitrectomy is indicated.

The sudden onset of floaters and/or the perception of flashes require urgent examination of the ocular fundus to rule out retinal injury!




Infants with leukocoria should be examined for the presence of life- or sight-threatening conditions, such as retinoblastoma.

Synchysis scintillans (cholesterolosis bulbi)

Asteroid hyalosis (synchysis nivea) [4]

  • Definition: degenerative liquefaction of the vitreous body involving vitreous opacities due to deposits of fatty calcium salts
  • Etiology
  • Clinical features
    • Usually asymptomatic
    • Unilateral floaters or vision loss may occur
  • Diagnostics
  • Treatment
    • Not indicated (since typically asymptomatic)
    • Vitrectomy if vision is significantly impaired

Floaters (mouches volantes, flying flies)

  • Etiology
  • Clinical features
    • Perception of opacities of various sizes and shapes (e.g., points, lines, filamentous structures)
    • Move as the eyes move and across the visual field
    • More intense when looking at bright, homogeneous areas (e.g., when looking at the sky or white paper)
  • Treatment: usually not pathological, but often considered disturbing by the patient

Watch out if there is a severe increase in floaters or photopsia occurs simultaneously. This can be a sign of retinal tearing and retinal detachment.

  1. Reichel E, Duker J, Goldman D, Fein J, Vora R. Handbook of Retinal Disease: a Case-based Approach. JP Medical Ltd ; 2015
  2. Medina CA, Townsend JH, Singh AD. Manual of Retinal Diseases. Springer ; 2016
  3. Vitreous Hemorrhage: Diagnosis and Treatment.
  4. Flaxel CJ, Adelman RA, Bailey ST, et al. Posterior Vitreous Detachment, Retinal Breaks, and Lattice Degeneration Preferred Practice Pattern®. Ophthalmology. 2020; 127 (1): p.P146-P181. doi: 10.1016/j.ophtha.2019.09.027 . | Open in Read by QxMD