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Elevated intracranial pressure and brain herniation

Last updated: February 24, 2021

Summarytoggle arrow icon

Intracranial pressure (ICP) is the pressure that exists within the skull and all of its compartments (e.g., the subarachnoid space and the ventricles). ICP varies with the relative position of the head towards the rest of the body and is periodically influenced by normal physiological factors (e.g., cardiac contractions). Adults in supine position have a physiological ICP of 15 mm Hg or less while a pressure of 20 mm Hg or more indicates pathological intracranial hypertension.

Elevation of ICP may occur in a variety of conditions (e.g., intracranial tumors) and can result in a decrease in cerebral perfusion pressure (CPP) and/or herniation of cerebral structures. Symptoms of raised ICP are generally nonspecific (e.g., impaired consciousness, headache, vomiting). However, more specific symptoms may be present depending on the affected structures (e.g., Cushing triad if the brainstem is compressed). Brain imaging (e.g., showing a midline shift) and physical examination (e.g., papilledema) can detect ICP elevation, but not necessarily rule it out. Therefore, ICP monitoring and quantification is vital in at-risk patients. Management usually involves osmotic diuretics such as mannitol or hypertonic saline. Further therapeutic options include controlled hyperventilation, removal of CSF, and decompressive craniectomy.



  • Physiological ICP is ≤ 15 mm Hg in adults (in supine position), children generally have a lower ICP
  • ICP varies with the relative position of the head towards the rest of the body and is influenced by certain physiological processes (e.g., cardiac contractions, sneezing, coughing, Valsalva maneuver).
  • Expansion of either blood, CSF, or tissue within the skull → limited capacity for the intracranial volume to increase within the rigid skull → increase in intracranial pressure

Consequences of elevated ICP



Cerebral herniation syndromes



Clinical examination and imaging may indicate elevated ICP, but cannot rule it out! Additionally, these tests do not allow quantification of intracranial pressure, which is necessary to determine CPP!

Invasive ICP monitoring

  • Indications
  • Placement of monitors
    • Intraventricular (gold standard)
      • Technique: implantation of monitoring device directly into the ventricles
      • Advantages: highest accuracy, allows for treatment of elevated ICP and/or diagnostic collection of CSF samples via drainage system
  • Analysis: > 20 mmHg indicates elevated intracranial pressure that requires treatment
    • ICP is not static but influenced by cardiac action and other factors. → ICP changes in a complex cyclic manner. → represented as distinct waveforms (normal, A wave, B wave, C wave)


Acute stabilization and treatment

ICP management

  • General approach
    • Goal of ICP management is generally to keep ICP < 20 mm Hg.
    • Positioning : e.g., head elevation (about 30 degrees), avoiding neck flexion/rotation or circumstances that may provoke Valsalva responses
    • Fluid management: patients should be euvolemic, blood hypoosmolarity should be avoided
    • Hyperventilation: up to a pCO2 of 26–30 mm Hg
    • Hypothermia
    • Causal treatment (e.g., removal of brain tumor) if possible
  • Medical therapy
    • Osmotic diuretics
      • IV mannitol: can generally be administered every 6–8 hours, effects last for up to 24 hours
      • IV hypertonic saline: particularly for short-term treatment
  • Removal of CSF via an intraventricular monitor with drainage system (e.g., external ventricular drain or lumbar drain) or a cerebral shunt (e.g., in hydrocephalus patients)
  • Decompressive craniectomy: removal of part of the skull, allowing the brain to expand and reduces ICP.


Irreversible loss of brain function (brain death)

  • Definition: irreversible, complete loss of function of the entire brain (including the brainstem), even if cardiopulmonary functions can be upheld by artificial life support.
  • Practical steps for determination of brain death: The American Academy of Neurology has published a practical guide that consists of four steps. It cites specific measures and interpretations (e.g., limits of body temperature) that can be used to determine brain death, although not all of them are evidence-based
  • Management

Requirements for the diagnosis of brain death

If spontaneous breathing is present, the medulla is intact! If the corneal reflex is present, the pons is intact! If the pupillary light reflex is present, the midbrain is intact!

Cerebral edema


We list the most important complications. The selection is not exhaustive.

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