Human echinococcosis, also known as hydatidosis or hydatid disease, is a parasitic disease caused by small tapeworms of the genus Echinococcus. The two most common forms of hydatidosis are cystic echinococcosis (CE), caused by E. granulosus, and alveolar echinococcosis (AE), caused by E. multilocularis. Infection occurs by ingesting Echinococcus eggs, most commonly via hand-to-mouth transmission or through food, water, or soil contaminated with feces. Following a long incubation period, infection with E. granulosus typically results in the formation of a single liver cyst (hydatid cyst), which may be asymptomatic or cause upper abdominal pain and other GI complaints. In contrast, infection with E. multilocularis resembles a hepatic malignancy that invades and destroys the surrounding tissue, which can lead to complications such as portal hypertension, cholangitis, jaundice, and even cirrhosis. Other extrahepatic manifestations may also occur as a result of metastasis to distant sites. Because of its malignant nature, AE is more difficult to treat and has a much higher mortality rate than CE. Treatment for both diseases consists of antihelminthic agents (e.g., albendazole or mebendazole), often in combination with surgical intervention.
Pathogens: Echinococcus tapeworms 
- Echinococcus granulosus causes CE
- Echinococcus multilocularis causes AE
- From the fur of definitive hosts (e.g., petting a dog or cat)
- Contaminated dirt (e.g., dog feces) 
- Fecal-contaminated food or water (e.g., wild berries, mushrooms) 
- Hosts 
- Life cycle: : The definitive host consumes hydatid cysts from an intermediate host → adult tapeworms develop and inhabit the small intestine → tapeworms produce eggs that are shed through stool, contaminating the ground → eggs are ingested by intermediate hosts → eggs hatch within the intestine and penetrate the intestinal wall → travel through the bloodstream and lymphatic system → liver or other organs → hydatid cysts 
|Features||Cystic echinococcosis||Alveolar echinococcosis|
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- Laboratory tests: (nonspecific; low diagnostic value): mild eosinophilia, leukopenia or thrombocytopenia, liver function abnormalities
- Serology: positive ELISA (false negatives are common)
- Cystic echinococcosis: unilocular, anechoic, smooth, well-defined hepatic cyst with or without daughter cysts
- Alveolar echinococcosis: lesions with irregular, poorly defined margins, central necrosis, and irregular calcifications within the cyst and cyst wall
- CT scan: indicated for further evaluation of cysts
- Observation: inactive cyst with heterogeneous hypoechoic/hyperechoic contents, or solid, calcified wall
- Medical therapy: may be considered as the sole treatment for cysts < 5 cm
- Ultrasonography/CT-guided percutaneous drainage
- Goal: resect the whole cyst to prevent spillage of its content
- Indications: > 10 cm, complicated cysts
- Follow-up: Because relapse is common, patients should be closely monitored via imaging for up to five years.
Any invasive procedure (drainage or surgery) of hydatid cysts should be performed with the utmost care to prevent spillage of cyst contents, which could cause life-threatening anaphylactic shock and/or secondary seeding of infection!