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Perinephric abscess

Last updated: March 17, 2021

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A perinephric abscess is a purulent infection located in the perinephric space between the kidney and the Gerota fascia. While it typically occurs secondary to acute pyelonephritis, it may also be caused by hematogenous spread of bacteria from elsewhere in the body (e.g., in IV drug users). Risk factors include diabetes mellitus, pregnancy, and urinary tract obstruction or abnormalities. Perinephric abscess is insidious in onset, with nonspecific symptoms that include flank or abdominal pain, fever, chills, and dysuria. Costovertebral angle tenderness is often present on examination. Abdominal CT is the preferred method to confirm the diagnosis. Abscess drainage and antibiotic therapy are the cornerstones of treatment. Complications include extension of the abscess beyond the Gerota fascia, into the retroperitoneum (paranephric abscess), and sepsis.

Onset is often insidious and symptoms are nonspecific, but they may include:

Laboratory tests


If possible, the abscess should be drained before empiric antibiotic therapy is initiated! However, if drainage is not immediately feasible, empiric antibiotics should be started.

“Ubi pus, ibi evacua” (Latin aphorism) – Where there is pus, evacuate it.

We list the most important complications. The selection is not exhaustive.

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  2. Balkan II, Savas A, Geduk A, Yemisen M, Mete B, Ozaras R. Candida glabrata perinephric abscess. Eurasian J Med. 2011; 43 (1): p.63-65. doi: 10.5152/eajm.2011.14 . | Open in Read by QxMD
  3. Jacobson D, Gilleland J, Cameron B, Rosenbloom E. Perinephric abscesses in the pediatric population: case presentation and review of the literature. Pediatr Nephrol. 2014; 29 (5): p.919-925. doi: 10.1007/s00467-013-2702-6 . | Open in Read by QxMD