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Viral hemorrhagic fevers

Last updated: July 27, 2020

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Viral hemorrhagic fevers (VHFs) are a group of viral infections caused by viruses from five different families: Arenaviridae, Bunyaviridae, Filoviridae, Flaviviridae, and Paramyxoviridae. The most well-known VHFs are Lassa fever, Hantavirus syndromes, Ebola virus disease, Dengue hemorrhagic fever, and yellow fever. Transmission of VHFs occurs via contact with their animal or insect reservoirs or vectors (e.g., rodents, mosquitoes, ticks). Human-to-human transmission is also possible, e.g., via bodily fluids. VHFs predominantly occur in tropical and subtropical regions. Clinical features of VHFs vary but often include an initial nonspecific flu-like illness that progresses to multisystem hemorrhage. VHFs are diagnosed via antibody detection (e.g., IgG, IgM), PCR, or immunohistochemistry. Treatment is typically supportive, but antivirals may be used in some cases (e.g., ribavirin in Lassa fever). Case fatality rates vary greatly between VHFs but can be up to 90%. Vaccines are licensed internationally for yellow fever only, so prevention primarily consists of infection control measures.

Overview of common viral hemorrhagic fevers
Family Virus Disease(s) Geography Transmission

Incubation period

Case fatality rate

Vaccine

Arenaviridae

Lassa virus

Lassa fever

  • West Africa (e.g., Liberia, Sierra Leone, Guinea)
  • Ingestion/inhalation of rodent urine or droppings from reservoir hosts of the virus: the multimammate rat
  • Contact with bodily fluids of other infected animals or humans
  • 1–21 days
  • Only ∼ 1% of infections are fatal
  • Mortality rate in those requiring hospitalization: 15–20%
  • None internationally licensed

Hantaviridae

Hantaviruses (especially Sin Nombre virus for HCPS)

Hantavirus cardiopulmonary syndrome (HCPS)

  • North and South America
  • Contact with infected rodent reservoir hosts or ingestion/inhalation of their blood, urine, droppings, or saliva
  • 1 –8 weeks
  • 35–45% in severe cases (bilateral infiltrates on chest x-ray)
  • Mild cases are not fatal.
  • None internationally licensed
Hemorrhagic fever with renal syndrome (HFRS)
  • Asia, Korea, Russia, Europe
  • Highest annual incidence in China
  • Contact with infected rodent reservoir hosts or ingestion/inhalation of their urine, droppings, or saliva
  • Up to 15%
Nairoviridae Crimean Congo hemorrhagic fever virus Crimean-Congo hemorrhagic fever
  • Southeastern Europe, Africa, Middle East, Asia
  • 1–13 days
  • Up to 80%
  • None internationally licensed
Phenuiviridae Rift valley fever virus Rift valley fever
  • Eastern and Southern Africa (e.g., Kenya, Tanzania, Somalia)
  • Sporadic cases also reported throughout Africa and the Middle East
  • Contact with infected livestock (i.e., bodily fluids)
  • Mosquito bites
  • 2–6 days
  • None internationally licensed
Filoviridae

Ebola virus

Ebola virus disease

  • Sub-Saharan Africa
  • Contact with bodily fluids of infected people, nonhuman primates (e.g., gorillas, chimpanzees, monkeys), or fruit bats
  • Direct contact with fomites increases the likelihood of nosocomial spread.
  • 2–21 days
Marburg virus Marburg hemorrhagic fever
  • Africa (e.g., Uganda, Zimbabwe, the Democratic Republic of the Congo)
  • Contact with the reservoir host of the virus, the African fruit bat
  • Contact with bodily fluids of infected individuals or animals
  • 5–10 days
  • 25–90%
  • None internationally licensed
Flaviviridae Dengue virus Dengue hemorrhagic fever
  • Worldwide in tropical regions of Central and South America, the Caribbean, Africa, and Asia
  • Mosquito bites
  • 4–10 days
  • 2–5%
Yellow fever virus Yellow fever
  • Tropical regions of South America and sub-Saharan Africa
  • Mosquito bites
  • 3–6 days
  • 30–60% of those who develop severe infection (The vast majority of infections are asymptomatic or very mild.)

Clinical features of VHFs vary depending on which virus is involved. Onset may be acute (e.g., Ebola virus disease) or insidious (e.g., Lassa fever) and often includes the following:

The differential diagnoses listed here are not exhaustive.

Aspirin and NSAIDs should be avoided in VHFs because they are associated with an increased risk of bleeding!

Immunization

See “Vaccine” in “Overview of viral hemorrhagic fevers” above.

Prevention

  • Avoid contact with blood, body fluids, or tissue from infected reservoirs or humans
  • Avoid travel to endemic areas
  • In suspected cases

Reportable disease

  • Probable, suspected, or confirmed cases of VHFs are notifiable conditions to local and state health authorities, as well as the CDC National Notifiable Disease Surveillance System.

There are two notable syndromes that can develop from a hantavirus infection: hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS)