Chickenpox (i.e., varicella) is an infection caused by the VZV). The condition predominantly affects children. Transmission occurs via inhalation of airborne droplets and direct contact with respiratory secretions or skin lesion fluids. Chickenpox manifests with an intensely pruritic rash characterized by sequential clusters of papules, vesicles, and pustules in various stages of development; the rash may be preceded by a prodrome of constitutional symptoms. A clinical diagnosis is made based on the appearance of the rash; confirmatory testing may be obtained for atypical rashes or severe infection. In immunocompetent individuals, chickenpox is self-limiting and managed symptomatically. Antiviral therapy is reserved for patients with severe infection or at high risk for complications (e.g., bacterial superinfection, invasive infections). Following resolution, the virus remains latent in the sensory nerve root ganglia; it can reactivate (see “Shingles”) during episodes of stress or immunosuppression. Prevention includes routine vaccination and, when indicated, .(
- Primarily occurs in children
- Before vaccines were widely introduced, ∼ 90% of all children had been infected by the age of 15.
Epidemiological data refers to the US, unless otherwise specified.
- Pathogen: : varicella zoster virus (VZV), a human herpesvirus type 3 (HHV-3) 
- Transmission 
- Highly contagious
- Two days before and up to five days after the onset of exanthem (or until all the lesions have formed crusts) 
- Latency: can become latent after primary infection and reside inside the trigeminal and/or 
Risk factors for severe VZV infection 
Individuals with any of the following factors are at risk of severe primary infection if they have no:
- Age > 12 years
- Chronic skin or lung disease 
- Long-term salicylate therapy (e.g., aspirin)
- Household exposure 
- Incubation period: ∼ 2 weeks 
- Prodrome phase (rare in children) 
Exanthem phase: characterized by approx. 250–500 severely pruritic lesions in varying stages of development ; 
- Lesion stages: papules→ superficial vesicles filled with clear fluid on an erythematous base (“dewdrop on rose petal” appearance) → umbilicated and crusted pustules → scabs fall off after 1–3 weeks, (often leaving a depressed base)
Skin involvement 
- Lesions first manifest centrally (i.e., face, scalp, and trunk) and spread to the extremities.
- The rash is ultimately distributed across the body, with the highest concentration of lesions in the centeral areas.
- The oral and urogenital mucous membranes are affected.
- Ocular involvement may be present (see “VZV conjunctivitis”).
- Palms and soles are typically spared.
- Features of severe varicella infection may develop, e.g.: 
- Latent phase: Following resolution of active skin infection, VZV remains latent in the sensory root ganglia; it can later reactivate (see "Shingles”).  
Severe varicella infection is characterized by the prolonged eruption of vesicles, which are sometimes hemorrhagic, high fever > 1 week, and dissemination of VZV to the brain (encephalitis), liver (hepatitis), and/or lungs (pneumonia). 
Subtypes and variants
Breakthrough varicella infection 
- Definition: a wild-type VZV infection that occurs in individuals who have received ≥ 1 dose of the ≥ 42 days prior to symptom onset 
- Infectivity: infectious to close contacts 
- Clinical features: generally mild compared to typical chickenpox infection 
- Diagnosis: PCR test confirms a wild-type strain of VZV; see “Diagnostics of chickenpox.” 
- Treatment: Usually supportive; follow measures to reduce spread.
Vaccine-associated chickenpox rash 
- Definition: A vaccine-type VZV infection that occurs following chickenpox immunization. 
- Incidence: manifests in 5–10% of healthy individuals following chickenpox immunization 
- Infectivity: may rarely infect close contacts 
- Clinical features
- Diagnosis: PCR testing of lesions confirms vaccine-type strain (i.e., Oka strain); see “Diagnostics of chickenpox.” 
- Treatment: supportive
- Typically diagnosed clinically based on characteristic clinical features
- Confirmatory diagnostic studies are usually only considered in the following cases: 
- Additional studies may be required for patients with severe infections.
Confirmatory studies 
- PCR (preferred test for active infection): detects VZV DNA 
- on vesicular fluid
- Serology (IgM and IgG detection) can identify primary infection and serologic immunity. 
- Viral culture 
- VZV (may also be positive in HSV infections): not specific for 
Chickenpox is usually diagnosed clinically. Obtain laboratory testing in case of atypical rash or severe infections. 
Consider in severe varicella zoster infection, depending on clinical features.
- Bacterial superinfection of lesions: See “Diagnostics for sepsis.”
- Pneumonia 
- Meningoencephalitis 
- Thrombocytopenia: CBC
Chickenpox may be confused with other conditions that involve widespread vesicles and/or crusting lesions, e.g.: 
- Disseminated shingles) (i.e.,
- : disseminated ,
- infection: atypical 
- Adverse reaction to smallpox vaccination: eczema vaccinatum, disseminated vaccinia 
- See also “Infectious rashes in childhood.”
The differential diagnoses listed here are not exhaustive.
- Start supportive treatment for all patients.
- Assess for indications for antiviral therapy for varicella; if present, determine duration of symptoms.
- Provide treatment for complications and superinfections (e.g., , ).
- Start measures to .
Most otherwise healthy children < 13 years of age with chickenpox can be treated with symptomatic treatment alone, but advise caregivers to return in the event of prolonged or worsening symptoms and/or signs of secondary bacterial skin infection. 
Supportive treatment 
- Treat fever and pain with acetaminophen. 
Pruritus ; 
- General advice for caregivers
- Apply cool compresses.
- Take lukewarm oatmeal baths.
- Trim fingernails or wear mitts to prevent scratching.
- Topical: calamine lotion, pramoxine gel 
- General advice for caregivers
Antiviral therapy for VZV infection (high-risk patients only)
- Indications for antiviral therapy
- Recommended treatment: Begin antiviral therapy as soon as possible (ideally within 24 hours of rash onset). ; 
Adults have higher rates of complications from varicella compared to children. 
- Bacterial superinfection; (including , , ), which often leads to scarring and is managed with antibiotics
- Reactivation of latent VZV results in shingles ( ).
Central nervous system 
- : good prognosis, mainly self-limiting after several weeks
- Encephalitis (very rare): cramps, coma, poor prognosis
- Pneumonia (viral or bacterial)
Fetus (chickenpox during pregnancy) 
We list the most important complications. The selection is not exhaustive.
- In healthy children, chickenpox infection generally has a benign course and heals without any consequences.
- Residual scarring may occur because of excessive scratching or bacterial superinfection.
- Immunosuppressed individuals are at a greater risk of the disease taking a generalized or even fatal course.
- Provide primary prevention against varicella infection.
- For infected patients: Initiate measures to limit transmission.
- For close contacts:
Most US states mandate reporting cases of chickenpox to local and/or state health departments. 
Evidence of VZV immunity 
Any of the following constitutes evidence of immunity to chickenpox: 
- Documentation of age-appropriate varicella immunization
- Laboratory findings that confirm prior wild-type disease or serologic evidence of immunity (see “Diagnostics of chickenpox”)
- Attestation of past varicella or herpes zoster infection by a healthcare provider
Varicella vaccine 
- General principles
- Schedule: See “ACIP immunization schedule” for details on routine and catch-up schedules.
- Adverse effects 
Postexposure prophylaxis for chickenpox 
- Postexposure prophylaxis is recommended for nonimmune individuals exposed to chickenpox or shingles to prevent disease onset or mitigate disease course. 
- Eligibility is determined by assessing for evidence of VZV immunity and verifying exposure.
- High-risk interactions include:
- Indoor face-to-face contact with an infected individual for ≥ 5 minutes 
- Sharing a hospital room or living arrangements with an infected individual
- Active or passive immunization is given depending on risk factors.
- For patients who are ineligible for active immunization and cannot receive passive immunization: Consult infectious disease about possible chemoprophylaxis. 
- Passive immunization may prolong the incubation period of VZV; monitor patients for 28 days following exposure. 
- If symptoms develop following exposure, initiate treatment for varicella infection regardless of whether the patient received postexposure prophylaxis.
Determining postexposure prophylaxis
|Recommended management |
|Evidence of VZV immunity||No evidence of VZV immunity|
- Indications: immunocompetent patients ≥ 12 months of age with no evidence of VZV immunity 
- Chickenpox immunization
- Give within 5 days following exposure (ideally within 3 days). 
- Follow-up vaccination: Complete the age-appropriate vaccination series per the immunization schedule.
Individuals with no evidence of VZV immunity who are:
- Patients who have undergone bone marrow transplantation 
- Neonates, if the mother was symptomatic 5 days before or up to 2 days after birth 
- Hospitalized premature babies if:
- Individuals with no evidence of VZV immunity who are:
- Recommended prophylaxis: Give as soon as possible within 10 days following exposure (ideally within 4 days). 
- Follow-up vaccination
Controlling varicella transmission in healthcare settings 
- Place patients with chickenpox on contact and airborne precautions (see “Infection prevention and control”). 
- All health care workers should have evidence of immunity to chickenpox.
- If a health care worker with no evidence of immunity is exposed, notify their supervisor and the occupational health department. 
Special patient groups
Varicella in pregnancy 
- Infection during pregnancy and the peripartum period is associated with significant complications.
- Pregnant woman: increased risk of varicella pneumonia 
- Fetus: 
- Neonate: 
- No modifications are required in pregnant patients.
- See “Diagnostics of chickenpox.”
- VZV diagnosed in pregnancy 
- VZV diagnosed in the peripartum period:
Prevention of varicella in pregnancy 
- Prior to pregnancy: Offer vaccination to patients with no evidence of VZV immunity who are willing to delay conception for 3 months. 
- During pregnancy:
- See also “Prevention of chickenpox.”
Pregnant women should not receive the varicella vaccine. Nonimmune women should be vaccinated after delivery. 
Varicella in adults 
- Adults are more likely than children to have a prodrome of fever and malaise prior to rash. 
- Adult patients are more likely to experience complications of varicella. 
- No modifications to diagnostics of chickenpox are required.
- For treatment of chickenpox in nonimmune adults, antiviral therapy is recommended.
Varicella in patients with HIV 
- Most adults with HIV have acquired varicella immunity prior to HIV infection.
- If infected, adults and adolescents with HIV are more likely to develop disseminated infection.
- See also “Cutaneous complications in HIV infection.”
- Antiviral treatment is recommended. 
- Discuss route of antiviral treatment with infectious diseases. 
- Uncomplicated infection is usually treated with oral antivirals
- Severe or complicated infection is usually treated with IV antivirals
- See also “Treatment of chickenpox.”