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Maternal complications during pregnancy

Last updated: December 29, 2021

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Nausea and vomiting are common conditions of pregnancy and are typically treated with hydration and nonpharmacologic methods. If nausea is refractory to nonpharmacologic methods, antiemetics should be started and added in a step-wise fashion. Hyperemesis gravidarum is a severe form of nausea and vomiting of pregnancy characterized by ketonuria and weight loss, and typically requires inpatient admission, intravenous fluid hydration, and antiemetic therapy. Cervical insufficiency refers to painless cervical dilation that occurs in the absence of uterine contractions and/or labor, usually in the second trimester of pregnancy, and that may require cervical cerclage. Other maternal complications of pregnancy include peripheral edema, gestational thrombocytopenia, and gestational diabetes.

In pregnant women, a thorough history, examination, and, if necessary, diagnostics are essential to rule out potential causes of nausea and vomiting that are not pregnancy-related.

Because antiemetics are potentially teratogenic, their use should be considered only if nausea and vomiting are refractory to dietary changes and supportive therapy.

A shortened cervical length alone is not sufficient to diagnose cervical insufficiency.

  1. Wegrzyniak LJ, Repke JT, Ural SH. Treatment of hyperemesis gravidarum.. Reviews in obstetrics & gynecology. 2012; 5 (2): p.78-84.
  2. Committee on Practice Bulletins-Obstetrics.. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy.. Obstet Gynecol. 2018; 131 (1): p.e15-e30. doi: 10.1097/AOG.0000000000002456 . | Open in Read by QxMD
  3. Quigley EMM, Hasler WL, Parkman HP. AGA technical review on nausea and vomiting. Gastroenterology. 2001; 120 (1): p.263-286. doi: 10.1053/gast.2001.20516 . | Open in Read by QxMD
  4. Quinlan JD, Hill DA. Nausea and vomiting of pregnancy. Am Fam Physician. 2003; 68 (1): p.121-128.
  5. Herell EH. Nausea and Vomiting of Pregnancy. Am Fam Physician.. undefined .
  6. Gabra A, Habib H, Gabra M. Hyperemesis Gravidarum, Diagnosis, and Pathogenesis. Critical Care Obstetrics and Gynecology. 2019; 05 (01). doi: 10.21767/2471-9803.1000172 . | Open in Read by QxMD
  7. Jennings LK, Krywko DM. Hyperemesis Gravidarum. StatPearls. 2021 .
  8. Petry CJ, Ong KK, Beardsall K, Hughes IA, Acerini CL, Dunger DB. Vomiting in pregnancy is associated with a higher risk of low birth weight: a cohort study. BMC Pregnancy Childbirth. 2018; 18 (1). doi: 10.1186/s12884-018-1786-1 . | Open in Read by QxMD
  9. Ferri FF. Ferri's Clinical Advisor 2017. Elsevier ; 2016 : p. 1345-1346
  10. Norwitz ER, Saade GA, Miller HS, Davidson CM. Obstetric Clinical Algorithms. Wiley-Blackwell ; 2016
  11. American College of Obstetricians and Gynecologists. Practice Bulletin No. 142: Cerclage for the Management of Cervical Insufficiency. Obstet Gynecol. 2014; 123 (2): p.372-379. doi: 10.1097/ . | Open in Read by QxMD
  12. Ressel GW. ACOG Releases Bulletin on Managing Cervical Insufficiency. Am Fam Physician. 2004; 69 (2): p.436-439.
  13. Ciobanu et al.. Thrombocytopenia in Pregnancy.. Maedica. 2016; 11 (1): p.55-60.