Vascular dementia (VD) describes gradual cognitive decline caused by small or large vessel disease. Important risk factors include hypertension, diabetes mellitus, hyperlipidemia, and advanced age. Large vessel changes primarily lead to thrombotic and/or embolic vascular occlusion, resulting in localized infarctions. In contrast, small vessel changes generally lead to more diffuse lesions. Common symptoms are cognitive impairment, motor disorders, and changes in behavior. The severity of symptoms and the mode of onset (insidious or sudden) depend on the number of vascular events and the extent of cerebral damage. Vascular dementia is primarily a clinical diagnosis that is supported by evidence of cerebrovascular lesions on imaging. Management consists of treating underlying conditions (e.g., hypertension) and, in some cases, antiplatelet drugs.
- VD may occur as a result of a prolonged and severe cerebral ischemia of any etiology, primarily: 
- Risk factors 
Small vessel disease 
- Predominantly caused by lipohyalinosis (hypertrophy of the vascular media combined with lipofibrous deposition within the vascular wall ), microatheroma, and/or amyloid beta deposition of cerebral vessels → thickening of the intima and/or the vessel wall, inflammation, thromboembolism → vessel stenosis, occlusion or rupture → cerebral ischemia → VD 
- Mainly causes infarcts or chronic ischemia in subcortical white matter (e.g., internal capsule) and/or in small penetrating arteries (lacunes) → diffuse white matter disease (infarctions or chronic ischemia), subcortical lacunar infarct, or the combination of both (known as Binswanger disease, which has multiple synonyms)
Large vessel disease
- Primarily caused by atherosclerosis (risk factors include hypertension, diabetes, and hyperlipidemia) 
- Usually in the form of repeated cortical ischemic events → progressive damage to neural networks (multi-infarct dementia) 
- If the affected area is large and/or significant enough (strategic infarctions ), a single ischemic event may suffice to bring on VD (single-infarct dementia). 
Symptoms depend on the location of ischemic events and therefore vary widely between individuals, but a progressive impairment of daily life is common. Because of the diverse clinical picture, the term “vascular cognitive impairment” is gaining popularity over VD. 
Dementia due to small vessel disease 
- Symptoms tend to progress gradually or stepwise and comparatively slower than in multi-infarct dementia.
- Generally associated with signs of subcortical pathology:
- Early symptoms
- Later symptoms
- Advanced stages
Dementia due to large vessel disease 
- Usually sudden onset
- Multi-infarct dementia: typically, stepwise deterioration
- Generally associated with signs of cortical pathology:
Subtypes and variants
- Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) 
- Brain MRI: : multiple cortical infarcts, subcortical infarcts (lacunes), and white matter lesions (periventricular and in the semioval center) 
- Brain CT scan: microangiopathic lesions located in white matter, multiple lacunar lesions in the subcortical brain regions
- Functional imaging (PET-CT): may be helpful in distinguishing between VD and Alzheimer disease (AD)
- Laboratory tests: (e.g., glucose levels, TSH): to rule out other potential causes or comorbidities
- The clinical findings of vascular dementia are often similar to other types of dementia (e.g., Alzheimer disease), however, there are some distinguishing features (see “ ”).
- Metabolic and endocrine disorders (e.g., vitamin B12 deficiency, hypothyroidism)
- Infections (e.g., neurosyphilis)
- Multiple sclerosis
- Space-occupying lesions (e.g., brain tumors or chronic subdural hematoma)
The differential diagnoses listed here are not exhaustive.