Celiac disease

Last updated: June 14, 2023

Summarytoggle arrow icon

Celiac disease, also referred to as celiac sprue or nontropical sprue, is a common condition characterized by a maladaptive immune response to gluten, a protein found in many grains (e.g., wheat). The disease often occurs in patients with other autoimmune illnesses, as both are associated with HLA variants (human leukocyte antigens, which encode immunoregulatory proteins) that cause pathologically increased immune responses. The underlying pathophysiology is believed to be a combination of gluten intolerance, which triggers an autoimmune reaction, and production of autoantibodies that target tissue transglutaminase, specifically within the proximal small intestine. Typical findings include changes in bowel habits and symptoms associated with malabsorption (e.g., fatigue, weight loss, vitamin deficiencies). Diagnostic tests include the detection of various antibodies. To confirm the diagnosis, an endoscopic biopsy from the small intestine is needed. Histopathological findings often include villous atrophy and crypt hyperplasia. A definitive diagnosis is necessary, as therapy involves a lifelong commitment to a gluten-free diet. If patients comply with this diet, the prognosis is generally very good and the increased risk of celiac-associated malignancies (e.g., intestinal lymphoma) is mitigated.

Definitiontoggle arrow icon

  • Definition: autoimmune disorder characterized by an intestinal hypersensitivity to gluten, a grain protein [1]
  • Synonyms: celiac sprue; gluten-sensitive enteropathy

Epidemiologytoggle arrow icon

  • Sex: >
  • Age of onset
    • The disease can occur at any age.
    • Peak incidence is bimodal:
      • At 8–12 months (or 2–3 months following the first exposure to gluten through diet containing wheat)
      • Third to fourth decade of life
  • Prevalence: in the US ∼ 1:150 [2]
  • Race: more common in individuals of northern European descent

Epidemiological data refers to the US, unless otherwise specified.

Etiologytoggle arrow icon

  • Genetic predisposition with association to HLA antigens [3]
    • HLA-DQ2 in 90–95% of patients
    • HLA-DQ8 in 5–10% of patients
  • Consuming gliadin from grains such as wheat, rye, and barley leads to an autoimmune reaction within the small intestinal wall.
  • Commonly associated with autoimmune diseases (see “Clinical features” below)

Pathophysiologytoggle arrow icon

Symptoms manifest when a genetically predisposed individual develops an immunological response to gliadin, an alcohol-soluble fraction of gluten.

Clinical featurestoggle arrow icon

Gastrointestinal symptoms

Extraintestinal symptoms and associations

In both children and adults, mild or asymptomatic cases are more common than the classic presentation of the disease.

Diagnosticstoggle arrow icon

General principles [5][6][7]

Laboratory studies [5][7]

Routine studies

  • IgA tissue transglutaminase antibody (tTG IgA): initial test, crucial part of celiac disease serology
  • Total IgA
    • Indicated for all patients because of the high prevalence of IgA deficiency in patients with celiac disease (approx. 2–3%) [3]
    • If patients have low IgA, perform further IgG-based testing.

Additional studies

Endoscopy [5][7]

False-negative serology and histopathology results are possible if patients are already adhering to a gluten-free diet.

Diagnosis without endoscopy [5][7]

  • Adults: diagnosis without biopsy not recommended.
  • Children: consider diagnosis without biopsy in case of high titers of tTG-IgA and positive EMA (controversial) [12][13]

Further evaluation


  • Repeat laboratory studies after 3–6 months and 12 months, then annually [5][7]
  • Endoscopy: only if symptoms persist or return in patients adhering to a gluten-free diet [5][6][8]

Differential diagnosestoggle arrow icon

Tropical sprue

Celiac disease and tropical sprue have similar features (e.g., steatorrhea, abdominal pain, weight loss), but only tropical sprue responds to antibiotics.

Whipple disease

Anyone who CANT appreciate the foamy, PAStoral rivers of England gets Whipped: the most important features of Whipple disease are Cardiac symptoms, Arthralgias, Neurologic symptoms, Trots (diarrhea), and foamy, PAS-positive macrophages on biopsy.

Whipple disease is lethal if left untreated.

The differential diagnoses listed here are not exhaustive.

Treatmenttoggle arrow icon

Diet [5][20]

  • Strict, lifelong gluten-free diet
    • Abstain from products containing wheat, rye, barley, or spelt.
    • Symptoms usually improve quickly [20]
  • Recommended foods: rice, corn, potatoes, soybeans, millet
  • Patients with secondary lactase deficiency: Avoid milk products.


Managing celiac disease mainly consists of maintaining a lifelong gluten-free diet.

Complicationstoggle arrow icon

We list the most important complications. The selection is not exhaustive.

Preventiontoggle arrow icon

  • There is no proven measure to prevent celiac disease.
  • With infants, introducing small amounts of wheat (into the supplementary diet) between 4–6 months of age does not increase the risk of developing celiac disease

Referencestoggle arrow icon

  1. Alaedini A, Green PH.. Autoantibodies in celiac disease. Autoimmunity. Autoimmunity. 2008; 41 (1): p.19-26.
  2. Rubio-Tapia A, Ludvigsson JF, Brantner TL, Murray JA, Everhart JE. The Prevalence of Celiac Disease in the United States. Am J Gastroenterol. 2012; 107 (10): p.1538-1544.doi: 10.1038/ajg.2012.219 . | Open in Read by QxMD
  3. Rubio-tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA. ACG clinical guidelines: diagnosis and management of celiac disease. The American Journal of Gastroenterology. 2013; 108 (5): p.656-76.doi: 10.1038/ajg.2013.79 . | Open in Read by QxMD
  4. Chin RL, Sander HW, Brannagan TH, et al.. Celiac neuropathy. Neurology. 2003; 60 (10): p.1581-5.
  5. Rubio-Tapia A, Hill ID, Semrad C, Kelly CP, Lebwohl B. American College of Gastroenterology Guidelines Update: Diagnosis and Management of Celiac Disease. Am J Gastroenterol. 2022; 118 (1): p.59-76.doi: 10.14309/ajg.0000000000002075 . | Open in Read by QxMD
  6. Leonard MM, Sapone A, Catassi C, Fasano A. Celiac Disease and Nonceliac Gluten Sensitivity: A Review. JAMA. 2017; 318 (7): p.647-656.doi: 10.1001/jama.2017.9730 . | Open in Read by QxMD
  7. Husby S, Murray JA, Katzka DA. AGA Clinical Practice Update on Diagnosis and Monitoring of Celiac Disease-Changing Utility of Serology and Histologic Measures: Expert Review. Gastroenterology. 2019; 156 (4): p.885-889.doi: 10.1053/j.gastro.2018.12.010 . | Open in Read by QxMD
  8. Oxentenko AS, Rubio-Tapia A. Celiac Disease. Mayo Clinic proceedings. 2019; 94 (12): p.2556-2571.doi: 10.1016/j.mayocp.2019.02.019 . | Open in Read by QxMD
  9. Hopper AD, Cross SS, Sanders DS. Patchy villous atrophy in adult patients with suspected gluten-sensitive enteropathy: is a multiple duodenal biopsy strategy appropriate?. Endoscopy. 2008; 40 (3): p.219-24.doi: 10.1055/s-2007-995361 . | Open in Read by QxMD
  10. Schiepatti A, Sanders DS, Zuffada M, Luinetti O, Iraqi A, Biagi F. Overview in the clinical management of patients with seronegative villous atrophy. Eur J Gastroenterol Hepatol. 2019; 31 (4): p.409-417.doi: 10.1097/MEG.0000000000001340 . | Open in Read by QxMD
  11. Enns RA, Hookey L, Armstrong D, et al. Clinical Practice Guidelines for the Use of Video Capsule Endoscopy. Gastroenterology. 2017; 152 (3): p.497-514.doi: 10.1053/j.gastro.2016.12.032 . | Open in Read by QxMD
  12. Hill ID, Dirks MH, Liptak GS, et al. Guideline for the Diagnosis and Treatment of Celiac Disease in Children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2005; 40 (1): p.1-19.doi: 10.1097/00005176-200501000-00001 . | Open in Read by QxMD
  13. Husby S, Koletzko S, Korponay-Szabó I, et al. European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020. J Pediatr Gastroenterol Nutr. 2020; 70 (1): p.141-156.doi: 10.1097/mpg.0000000000002497 . | Open in Read by QxMD
  14. Wierdsma NJ, van Bokhorst-de van der Schueren MA, Berkenpas M, Mulder CJ, van Bodegraven AA. Vitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients. Nutrients. 2013; 5 (10): p.3975-92.doi: 10.3390/nu5103975 . | Open in Read by QxMD
  15. Kreutz JM, Adriaanse MPM, van der Ploeg EMC, Vreugdenhil ACE. Narrative Review: Nutrient Deficiencies in Adults and Children with Treated and Untreated Celiac Disease. Nutrients. 2020; 12 (2).doi: 10.3390/nu12020500 . | Open in Read by QxMD
  16. He L, Li ZB, Zhu HD, Wu XL, Tian DA, Li PY. The prediction value of scoring systems in Mallory-Weiss syndrome patients.. Medicine. 2019; 98 (22): p.e15751.doi: 10.1097/MD.0000000000015751 . | Open in Read by QxMD
  17. Dutly F, Altwegg M. Whipple's Disease and "Tropheryma whippelii". Clin Microbiol Rev. 2001; 14 (3): p.561-583.doi: 10.1128/cmr.14.3.561-583.2001 . | Open in Read by QxMD
  18. Antunes C, Singhal M. Whipple Disease. StatPearls. 2021.
  19. J. Kucharz E, Kramza J, Grosicka A, Pieczyrak R. Clinical manifestations of Whipple’s disease mimicking rheumatic disorders. Rheumatology. 2021; 59 (2): p.104-110.doi: 10.5114/reum.2021.105418 . | Open in Read by QxMD
  20. Murray JA, Watson T, Clearman B, Mitros F. Effect of a gluten-free diet on gastrointestinal symptoms in celiac disease. Am J Clin Nutr. 2004; 79 (4): p.669-73.doi: 10.1093/ajcn/79.4.669 . | Open in Read by QxMD
  21. Han Y, Chen W, Li P, Ye J. Association Between Coeliac Disease and Risk of Any Malignancy and Gastrointestinal Malignancy. Medicine. 2015; 94 (38): p.e1612.doi: 10.1097/md.0000000000001612 . | Open in Read by QxMD
  22. Hill ID, Fasano A, Guandalini S, et al. NASPGHAN Clinical Report on the Diagnosis and Treatment of Gluten-related Disorders. J Pediatr Gastroenterol Nutr. 2016; 63 (1): p.156-65.doi: 10.1097/MPG.0000000000001216 . | Open in Read by QxMD

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