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Urinary tract infections

Last updated: August 16, 2021

Summarytoggle arrow icon

Urinary tract infections (UTIs) are infections of the bladder, urethra, ureters, or kidneys that are most commonly caused by bacteria, especially E. coli. Infections of the bladder or urethra are called lower UTIs, whereas infections involving the kidneys or ureters are called upper UTIs. Because women have a shorter urethra and anal and genital regions that are closer in proximity, they are at higher risk of contracting UTIs than men. Other risk factors include sexual intercourse, indwelling urinary catheters, pregnancy, and abnormalities of the urinary tract. UTIs in otherwise healthy, nonpregnant, and premenopausal women are considered uncomplicated. UTIs in men or patients with other risk factors for treatment failure or serious outcomes, such as functional or anatomical abnormalities of the urinary tract, are considered complicated. Clinical findings depend on which part of the urinary tract is affected. Lower UTIs manifest with dysuria, suprapubic pain, urinary urgency, and increased urinary frequency, whereas upper UTIs additionally cause fever and flank pain. Diagnosis is usually clinical and can be supported with findings of pyuria and bacteriuria on urinalysis. Further evaluation with urine culture and/or imaging may be required for patients with complicated cystitis or equivocal urinalysis findings. Antibiotic treatment regimens depend on the location and severity of infection. First-line empiric antibiotic therapy options for uncomplicated lower UTIs include oral nitrofurantoin, trimethoprim-sulfamethoxazole, and fosfomycin for up to 7 days. For complicated lower UTIs, broad-spectrum antibiotic therapy should be given for 7–14 days and treatable complicating factors should be addressed. Recurrent UTIs are common in women and antibiotic prophylaxis may be indicated. Catheter-associated urinary tract infections (CAUTI) are among the most common healthcare-associated infections; they are frequently caused by resistant bacteria and are treated with catheter removal or replacement in addition to antibiotic therapy. Pregnant women should be screened and treated both for UTIs and for asymptomatic bacteriuria. For the management of upper UTIs, see “Pyelonephritis.”

Pathogens

Bacteria

Viruses

Other pathogens

Predisposing factors

Host-dependent factors

Other factors

SEEK PP = S - S. saprophyticus, E - E. coli, E - Enterococcus, K - Klebsiella, P - Proteus, P - Pseudomonas are the bacteria commonly associated with UTIs.

Urinary tract infections are classified and treated based on location, severity, source of infection, and frequency. The presence of symptoms distinguishes UTI from asymptomatic bacteriuria, which only requires treatment in a select subset of patients.

Classification of urinary tract infections [7]
Details
By clinical presentation [8] Asymptomatic bacteriuria (ASB)
Urinary tract infection (UTI)
By location [9] Lower UTI

Upper UTI

By severity [10][11][12] Uncomplicated UTI
  • Infection in nonpregnant, premenopausal women without further risk factors for infection, treatment failure, or serious outcomes
Complicated UTI (cUTI)
Urosepsis
  • UTI that leads to life-threatening organ dysfunction (see “Sepsis”) [13]
By source of infection [14][15] Community-acquired UTI
  • UTI acquired outside of a healthcare setting and/or UTI that manifests within 48 hours of hospital admission
Healthcare-associated UTI
By frequency [8] Recurrent UTI
  • ≥ 3 episodes of symptomatic, culture-proven UTI in one year or ≥ 2 episodes in 6 months

Since fever is usually absent in lower UTIs, the presence of fever and flank pain should be considered a sign of more serious infection, e.g., pyelonephritis.

Approach [7][22]

Symptomatic, uncomplicated lower UTIs can be diagnosed clinically. In all other patients, urinalysis is the most important initial diagnostic test.

UTI is primarily a clinical diagnosis that is supported by typical findings on urinalysis. Urine culture is indicated in select cases to determine the causative pathogen and adapt antibiotic treatment.

Laboratory studies [23]

Urinalysis [23][24]

Urine culture [7][12][23]

In patients with complicated or recurrent urinary tract infections, a urine culture should be obtained prior to initiating antibiotic treatment. False negative results are possible if a culture is obtained after the patient has received antibiotics.

Additional diagnostics [13][22][30]

Imaging [12][13][31]

Imaging is generally not indicated or helpful for the diagnosis of lower UTI, but it may be performed in select patients to rule out complicating factors (e.g., urinary tract obstruction) or if complicated pyelonephritis or urosepsis are suspected. For imaging indications and findings in upper UTI, see “Diagnostics” in “Pyelonephritis.”

Imaging is not routinely necessary for patients with uncomplicated lower UTI.

Interstitial cystitis (painful bladder syndrome) [32][33]

Asymptomatic bacteriuria (ASB) [25][39]

  • Description
    • Presence of ≥ 100,000 CFU/mL in at least two voided urine samples in patients with no symptoms of UTI; (e.g., dysuria, frequency, urgency, suprapubic pain)
    • Bacteriuria typically resolves spontaneously in healthy, nonpregnant women without any side effects.
    • Women with asymptomatic bacteriuria may progress to symptomatic UTI in the future more often than women with no bacteriuria.
  • Epidemiology
    • Prevalence
      • Occurs in 1–5% of healthy, premenopausal women and in 2–10% of pregnant women
      • Occurs in 9–25% of elderly individuals and individuals with diabetes, indwelling catheters, or spinal cord injuries
  • Etiology: E. coli is the most common causative organism.
  • Risk factors
  • Diagnosis: urinalysis with microscopy
    • Mid-stream urine sample: bacterial growth ≥ 100,000 CFU/mL in two consecutive samples in women or in one sample in men
    • Catheterized urine sample: bacterial growth ≥ 100,000 CFU/mL with one bacterial species isolated in women or men
  • Management

Other differential diagnoses

The differential diagnoses listed here are not exhaustive.

General principles [7][12][22][42]

  • Antibiotic treatment is recommended for all patients with symptomatic UTI.
    • The optimal therapy depends on disease severity, local resistance patterns, and patient characteristics (e.g., allergies).
    • Initial treatment is with an empiric regimen, which is maintained for uncomplicated cystitis.
    • In unclear or complicated cases, the regimen may subsequently have to be adjusted based on urine culture data.
  • Consider the need for supportive treatment.
    • Phenazopyridine, a urinary analgesic, can be used for symptomatic relief for a maximum of 2 days.
    • Oral analgesia, e.g., with NSAIDs, can provide additional relief.
  • For the treatment of upper UTI, see “Treatment of pyelonephritis.”

Uncomplicated lower UTI [12][42][43]

  • Management can typically be done in the outpatient setting with oral therapy.
  • Treatment duration depends on the chosen antibiotic agent.
  • Symptom relief can be expected to occur after an average of 36 hours. [28]
  • Persistent symptoms despite antibiotic therapy suggest complicated UTI and/or indicate the need to change the empiric therapy.

Antibiotic treatment of uncomplicated lower UTIs

Complicated lower UTI [7][12][44][45]

Antibiotic treatment of complicated lower UTIs [12][44]

Treatment regimens for UTI in men should include antibiotics that are able to penetrate prostate tissue (e.g., fluoroquinolones or TMP-SMX). Fosfomycin or nitrofurantoin are generally not adequate.

Management of complicating factors

  • Nephrolithiasis: In UTI with renal obstruction, urgent urology consultation is required for drainage. [48]
  • Indwelling medical devices (e.g., ureteral stents, percutaneous nephrostomy tubes) [49][50]
    • Management of infections may require exchange or removal of the device, especially when it is obstructed.
    • Urology should be consulted urgently for further management.
  • Other treatable factors should be addressed: e.g., optimal blood sugar control for diabetics.

Recurrent UTI [8][51]

Recurrent UTIs are common in women. Management involves the implementation of preventive measures and antibacterial prophylaxis in addition to the antibiotic treatment of acute episodes.

Acute management

Chemoprophylaxis [8]

Nonantibiotic prophylaxis

  • Cranberry products have shown moderate benefit and are associated with little risk.
  • Topical estrogen therapy should be considered in postmenopausal women.
  • Behavioral modifications (e.g., increased fluid intake, postcoital voiding) may be helpful.

Candiduria [52]

  • Candida isolated from the urine rarely indicates systemic infection, but it may be a marker for greater mortality in severely ill patients.
  • Predisposing factors should be treated in all cases of candiduria, e.g., by removing indwelling catheters whenever possible.
  • Indications for antifungal treatment include symptomatic cystitis or pyelonephritis, neutropenia, or a planned urologic procedure.
  • Commonly used antifungals include fluconazole and amphotericin B.
  • Consult the infectious disease service for assistance with appropriate antifungal treatment.

We list the most important complications. The selection is not exhaustive.

Overview [12][14]

Diagnostics

A urine culture, ideally obtained prior to antibiotic treatment, is always required to diagnose CAUTI.

  • Indications: features consistent with potential infection
  • Specimen collection: ideally from the sampling port of a newly inserted device using aseptic technique [56]
  • Diagnostic criteria

Treatment

UTI in elderly patients [57]

  • UTI is very common in advanced age, both in individuals who live in long-term care facilities and those who do not.
  • Symptoms of UTI are more commonly atypical (e.g., back pain, pelvic pain, constipation, urinary incontinence, and altered mental status).
  • Management principles are generally the same as outlined above.
  • Preventative strategies include increasing mobility and consumption of cranberry products.

UTI during pregnancy [58]

Pathophysiology

Asymptomatic bacteriuria in pregnancy [12][59]

Treatment of ASB and lower UTIs in pregnant women [12][60]

Although UTI in pregnant patients is generally considered complicated, treatment regimens may include those typically used for uncomplicated UTI and should be adapted to the patient's individual risk and urine culture results.

Asymptomatic bacteriuria in pregnancy is a risk factor for pyelonephritis and should be treated.

UTI in children and adolescents [61][62]

Epidemiology

  • UTIs are common in children.
  • Approx. 8% of girls and 2% of boys will have had a UTI by the age of 7 years.

Risk factors

Diagnosis

Treatment

  • Treatment principles in children are similar to those in adults.
  • Empiric therapy
  • When associated with structural abnormalities, additional management of the underlying condition may be required.

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  1. Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2). McGraw-Hill Education / Medical ; 2018
  2. Anger J, Lee U, Ackerman AL, et al. Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline. J Urol. 2019; 202 (2): p.282-289. doi: 10.1097/ju.0000000000000296 . | Open in Read by QxMD
  3. Katz MH, Doherty GM. Current Diagnosis and Treatment Surgery, 15th Edition. McGraw-Hill Education / Medical ; 2020
  4. Hooton TM. Uncomplicated Urinary Tract Infection. N Engl J Med. 2012; 366 (11): p.1028-1037. doi: 10.1056/nejmcp1104429 . | Open in Read by QxMD
  5. Colgan R, Williams M. Diagnosis and treatment of acute uncomplicated cystitis.. Am Fam Physician. 2011; 84 (7): p.771-6.
  6. 2021 EAU Guideline on Urological Infections. https://web.archive.org/web/20210611080346/https://uroweb.org/guideline/urological-infections/. Updated: March 1, 2021. Accessed: June 11, 2021.
  7. Walls R, Hockberger R, Gausche-Hill M. Rosen's Emergency Medicine. Elsevier Health Sciences ; 2018
  8. Hooton TM, Bradley SF, Cardenas DD, et al. Diagnosis, Prevention, and Treatment of Catheter-Associated Urinary Tract Infection in Adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin Infect Dis. 2010; 50 (5): p.625-663. doi: 10.1086/650482 . | Open in Read by QxMD
  9. Cardoso T, Almeida M, Friedman ND, et al. Classification of healthcare-associated infection: a systematic review 10 years after the first proposal. BMC Med. 2014; 12 (1). doi: 10.1186/1741-7015-12-40 . | Open in Read by QxMD
  10. Magill SS, Edwards JR, Bamberg W, et al. Multistate point-prevalence survey of health care-associated infections. N Engl J Med. 2014; 370 (13): p.1198-1208. doi: 10.1056/NEJMoa1306801 . | Open in Read by QxMD
  11. Ronald A. The etiology of urinary tract infection: traditional and emerging pathogens. Am J Med. 2002; 113 (1): p.14-19. doi: 10.1016/s0002-9343(02)01055-0 . | Open in Read by QxMD
  12. Medical Student Curriculum: Pediatric Urinary Tract Infections. https://www.auanet.org/education/auauniversity/for-medical-students/medical-students-curriculum/medical-student-curriculum/pediatric-uti. Updated: July 1, 2016. Accessed: November 15, 2019.
  13. Paduch DA. Viral lower urinary tract infections.. Curr Urol Rep. 2007; 8 (4): p.324-35. doi: 10.1007/s11934-007-0080-y . | Open in Read by QxMD
  14. Fischer C. Master the Boards USMLE Step 2 CK. Kaplan Publishing ; 2013
  15. Ahmad Nikibakhsh. Clinical Management of Complicated Urinary Tract Infection. InTech ; 2011
  16. Shapiro E. American academy of pediatrics policy statements on circumcision and urinary tract infection.. Rev Urol. 1999; 1 (3): p.154-6.
  17. Miller JM, Binnicker MJ, Campbell S, et al. A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology. Clin Infect Dis. 2018; 67 (6): p.e1-e94. doi: 10.1093/cid/ciy381 . | Open in Read by QxMD
  18. Flores-Mireles et al. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nature Reviews Microbiology. 2015; 13 (5): p.269-284. doi: 10.1038/nrmicro3432 . | Open in Read by QxMD
  19. Hooton TM, Gupta K. Acute Uncomplicated Cystitis in Women. In: Post TW, ed. UpToDate. Waltham, MA: UpToDate. https://www.uptodate.com/contents/acute-uncomplicated-cystitis-in-women.Last updated: December 6, 2017. Accessed: April 4, 2018.
  20. Hooton TM, Gupta K. Acute Complicated Urinary Tract Infection (Including Pyelonephritis) in Adults. In: Post TW, ed. UpToDate. Waltham, MA: UpToDate. https://www.uptodate.com/contents/acute-complicated-urinary-tract-infection-including-pyelonephritis-in-adults.Last updated: March 16, 2018. Accessed: April 4, 2018.
  21. Korbel L, Howell M, Spencer JD. The clinical diagnosis and management of urinary tract infections in children and adolescents. Paediatrics and International Child Health. 2017; 37 (4): p.273-279. doi: 10.1080/20469047.2017.1382046 . | Open in Read by QxMD
  22. Kuswardhani RAT, Sugi YS. Factors Related to the Severity of Delirium in the Elderly Patients With Infection. Gerontology and Geriatric Medicine. 2017; 3 : p.233372141773918. doi: 10.1177/2333721417739188 . | Open in Read by QxMD
  23. Gupta K. Urinary Tract Infection. Ann Intern Med. 2012; 156 (5): p.ITC3. doi: 10.7326/0003-4819-156-5-201203060-01003 . | Open in Read by QxMD
  24. Wilson ML, Gaido L. Laboratory Diagnosis of Urinary Tract Infections in Adult Patients. Clin Infect Dis. 2004; 38 (8): p.1150-1158. doi: 10.1086/383029 . | Open in Read by QxMD
  25. Simerville JA, Maxted WC, Pahira JJ. Urinalysis: a comprehensive review.. Am Fam Physician. 2005; 71 (6): p.1153-62.
  26. Colgan R, Nicolle LE, McGlone A, Hooton TM. Asymptomatic bacteriuria in adults.. Am Fam Physician. 2006; 74 (6): p.985-90.
  27. Brown PD. Management of Urinary Tract Infections Associated with Nephrolithiasis. Curr Infect Dis Rep. 2010; 12 (6): p.450-454. doi: 10.1007/s11908-010-0141-0 . | Open in Read by QxMD
  28. Mody L, Juthani-Mehta M. Urinary Tract Infections in Older Women. JAMA. 2014; 311 (8): p.844. doi: 10.1001/jama.2014.303 . | Open in Read by QxMD
  29. Colgan, Williams. Diagnosis and Treatment of Acute Uncomplicated Cystitis. American Family Physician. 2011 .
  30. Doern CD, Richardson SE. Diagnosis of Urinary Tract Infections in Children. J Clin Microbiol. 2016; 54 (9): p.2233-2242. doi: 10.1128/jcm.00189-16 . | Open in Read by QxMD
  31. Beth N. Peshkin, MS, CGC,Michelle L. Alabek, MS, and Claudine Isaacs, MD. BRCA1/2 mutations and triple negative breast cancers.. Breast Disease. 2010 .
  32. Venkatesan AM, Oto A, Allen BC, et al. ACR Appropriateness Criteria® Recurrent Lower Urinary Tract Infections in Females. J Am Coll Radiol. 2020; 17 (11): p.S487-S496. doi: 10.1016/j.jacr.2020.09.003 . | Open in Read by QxMD
  33. Hanno PM, Erickson D, Moldwin R, et al. Diagnosis and treatment of interstitial cystitis/bladder pain syndrome: AUA guideline amendment. J Urol. 2015; 193 (5): p.1545-1553. doi: 10.1016/j.juro.2015.01.086 . | Open in Read by QxMD
  34. American Urological Association: Diagnosis and Treatment Interstitial Cystitis/Bladder Pain Syndrome Guideline. https://www.auanet.org/guidelines/interstitial-cystitis-(ic/bps)-guideline. Updated: January 1, 2014. Accessed: July 31, 2020.
  35. McKernan LC, Walsh CG, Reynolds WS, Crofford LJ, Dmochowski RR, Williams DA. Psychosocial co-morbidities in Interstitial Cystitis/Bladder Pain syndrome (IC/BPS): A systematic review. Neurourol Urodyn. 2017; 37 (3): p.926-941. doi: 10.1002/nau.23421 . | Open in Read by QxMD
  36. Clauw DJ, Schmidt M, Radulovic D, Singer A, Katz P, Bresette J. The relationship between fibromyalgia and interstitial cystitis.. J Psychiatr Res. 1997; 31 (1): p.125-31. doi: 10.1016/s0022-3956(96)00051-9 . | Open in Read by QxMD
  37. Watkins KE, Eberhart N, Hilton L, et al. Depressive disorders and panic attacks in women with bladder pain syndrome/interstitial cystitis: a population-based sample. Gen Hosp Psychiatry. 2011; 33 (2): p.143-149. doi: 10.1016/j.genhosppsych.2011.01.004 . | Open in Read by QxMD
  38. Kuo Y-C, Kuo H-C. O’Leary-Sant Symptom Index Predicts the Treatment Outcome for OnabotulinumtoxinA Injections for Refractory Interstitial Cystitis/Bladder Pain Syndrome. Toxins. 2015; 7 (8): p.2860-2871. doi: 10.3390/toxins7082860 . | Open in Read by QxMD
  39. Bosch PC. Examination of the Significant Placebo Effect in the Treatment of Interstitial Cystitis/Bladder Pain Syndrome. Urology. 2014; 84 (2): p.321-326. doi: 10.1016/j.urology.2014.04.011 . | Open in Read by QxMD
  40. Guidelines on Urological infections 2019. https://uroweb.org/wp-content/uploads/EAU-Guidelines-on-Urological-infections-2019.pdf. Updated: March 1, 2019. Accessed: August 12, 2020.
  41. Asymptomatic Bactetiuria. https://www.aafp.org/afp/2020/0715/p99.html. Updated: July 15, 2020. Accessed: August 18, 2020.
  42. Le T, Bhushan V, Chen V, King M. First Aid for the USMLE Step 2 CK. McGraw-Hill Education ; 2015
  43. Gupta K, Hooton TM, Naber KG, et al. International Clinical Practice Guidelines for the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women: A 2010 Update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clinical Infectious Diseases. 2011; 52 (5): p.e103-e120. doi: 10.1093/cid/ciq257 . | Open in Read by QxMD
  44. Lee RA, Centor RM, Humphrey LL, Jokela JA, Andrews R, Qaseem A. Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians. Ann Intern Med. 2021 . doi: 10.7326/m20-7355 . | Open in Read by QxMD
  45. Murphy JE, Lee MW-L. PSAP 2018 Book 1: Infectious Diseases. American College of Clinical Pharmacy ; 2018
  46. Levison ME, Kaye D. Treatment of Complicated Urinary Tract Infections With an Emphasis on Drug-Resistant Gram-Negative Uropathogens. Curr Infect Dis Rep. 2013; 15 (2): p.109-115. doi: 10.1007/s11908-013-0315-7 . | Open in Read by QxMD
  47. Bennett JE, Dolin R, Blaser MJ. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Elsevier ; 2019
  48. Derington CG, Benavides N, Delate T, Fish DN. Multiple-Dose Oral Fosfomycin for Treatment of Complicated Urinary Tract Infections in the Outpatient Setting. Open Forum Infect Dis. 2020; 7 (2). doi: 10.1093/ofid/ofaa034 . | Open in Read by QxMD
  49. Assimos D, Krambeck A, Miller NL et al. Surgical Management of Stones: American Urological Association/Endourological Society Guideline, PART II. J Urol. 2016; 196 (4): p.1161-1169. doi: 10.1016/j.juro.2016.05.091 . | Open in Read by QxMD
  50. Dyer RB, Chen MY, Zagoria RJ, Regan JD, Hood CG, Kavanagh PV. Complications of Ureteral Stent Placement. RadioGraphics. 2002; 22 (5): p.1005-1022. doi: 10.1148/radiographics.22.5.g02se081005 . | Open in Read by QxMD
  51. Huang S, Philip A, Richter M, Gupta S, Lessne M, Kim C. Prevention and Management of Infectious Complications of Percutaneous Interventions. Semin Intervent Radiol. 2015; 32 (02): p.078-088. doi: 10.1055/s-0035-1549372 . | Open in Read by QxMD
  52. Kodner CM, Thomas Gupton EK. Recurrent urinary tract infections in women: diagnosis and management.. Am Fam Physician. 2010; 82 (6): p.638-43.
  53. Pappas PG, Kauffman CA, Andes DR et al. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2015; 62 (4): p.e1-e50. doi: 10.1093/cid/civ933 . | Open in Read by QxMD
  54. Loh K, Sivalingam N. Urinary tract infections in pregnancy.. Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia. 2007; 2 (2): p.54-7.
  55. Verma I, Avasthi K, Berry V. Urogenital infections as a risk factor for preterm labor: a hospital-based case-control study.. J Obstet Gynaecol India. 2014; 64 (4): p.274-8. doi: 10.1007/s13224-014-0523-6 . | Open in Read by QxMD
  56. Ghouri F, Hollywood A, Ryan K. A systematic review of non-antibiotic measures for the prevention of urinary tract infections in pregnancy.. BMC Pregnancy Childbirth. 2018; 18 (1): p.99. doi: 10.1186/s12884-018-1732-2 . | Open in Read by QxMD
  57. Rowe TA, Juthani-Mehta M. Diagnosis and Management of Urinary Tract Infection in Older Adults. Infect Dis Clin North Am. 2014; 28 (1): p.75-89. doi: 10.1016/j.idc.2013.10.004 . | Open in Read by QxMD
  58. Schnarr J, Smaill F. Asymptomatic bacteriuria and symptomatic urinary tract infections in pregnancy. Eur J Clin Invest. 2008; 38 : p.50-57. doi: 10.1111/j.1365-2362.2008.02009.x . | Open in Read by QxMD
  59. Nicolle LE, Gupta K, Bradley SF, et al. Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2019 . doi: 10.1093/cid/ciy1121 . | Open in Read by QxMD
  60. Bookstaver PB, Bland CM, Griffin B, Stover KR, Eiland LS, McLaughlin M. A Review of Antibiotic Use in Pregnancy. Pharmacotherapy. 2015; 35 (11): p.1052-1062. doi: 10.1002/phar.1649 . | Open in Read by QxMD
  61. Diagnosis and Treatment of Urinary Tract Infections in Children. https://www.aafp.org/afp/2011/0215/p409.html. Updated: February 15, 2011. Accessed: August 5, 2020.
  62. Kaufman J, Temple-Smith M, Sanci L. Urinary tract infections in children: an overview of diagnosis and management. BMJ Paediatrics Open. 2019; 3 (1): p.e000487. doi: 10.1136/bmjpo-2019-000487 . | Open in Read by QxMD